Related Experiment Video
Updated: Aug 5, 2026

Development of a Hepatitis B Virus Reporter System to Monitor the Early Stages of the Replication Cycle
Published on: February 1, 2017
RNA sequence of potato virus X strain HB
M Querci1, R van der Vlugt, R Goldbach
1International Potato Center, Lima, Peru.
Abstract:
The genomic RNA of the potato virus X (PVX) strain HB, isolated in Bolivia and able to overcome all known resistance genes, has been cloned and sequenced. The PVXHB RNA sequence is 6432 nucleotides long and contains, similarly to the RNAs of other PVX strains, five open reading frames encoding proteins of M(r)s 165.1K, 24.5K, 12.4K, 7.6K and 25.1K (coat protein), respectively. Multiple amino acid sequence alignments of the coat proteins of four PVX strains identified eight amino acid residues unique for PVXHB. Structural prediction comparisons of the coat proteins of PVXHB and of the other strains suggest a general structural similarity. However, two of the eight amino acid residues unique for strain HB gave rise to a change in the predicted coat protein structure, suggesting a possible involvement in the resistance-breaking activity of PVXHB.
Related Concept Videos
Leaky Scanning
Viruses with RNA Genomes
Subviral Agents
Hepatitis
Antiviral Nucleoside Inhibitors
Viral Hepatitis I: Introduction

