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Related Experiment Videos

Viral infections trigger multiple sclerosis relapses: a prospective seroepidemiological study

O Andersen1, P E Lygner, T Bergström

  • 1Department of Neurology, University of Gothenburg, Sweden.

Journal of Neurology
|July 1, 1993
PubMed
Summary

Common infections, particularly adenovirus, significantly increase multiple sclerosis (MS) relapse risk. This study highlights the link between viral infections and MS activity, suggesting a need for epidemiological surveillance.

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Area of Science:

  • Neurology
  • Epidemiology
  • Immunology

Background:

  • Multiple sclerosis (MS) is a chronic neurological disease.
  • The role of systemic infections in triggering MS relapses is not fully understood.
  • Understanding these triggers is crucial for managing MS activity.

Purpose of the Study:

  • To investigate the association between common infections and multiple sclerosis relapses.
  • To determine if specific viral infections correlate with increased MS relapse rates.
  • To explore the seasonal patterns of MS relapses.

Main Methods:

  • Prospective surveillance of 60 benign MS patients over 31 months.
  • Recording of upper respiratory and gastrointestinal infections.
  • Serological diagnosis of five common viral infections and neurological relapse monitoring.

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Main Results:

  • A significant increase in MS relapses (relative risk 1.3) was observed during infection periods.
  • MS relapse rates showed seasonal variation, with a summer minimum.
  • Adenovirus infections correlated with major MS relapses, unlike influenza.

Conclusions:

  • Common infections, especially adenovirus, are linked to increased MS relapse risk.
  • Linear homologies between adenovirus and myelin protein may explain the association.
  • Epidemiological surveillance is vital for understanding MS triggers.