Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Chronic lymphocytic leukemia with CNS involvement

S Pohar1, C deMetz, S Poppema

  • 1Department of Radiation Therapy, Cleveland Clinic Foundation, Ohio 44195.

Journal of Neuro-Oncology
|April 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Corrigendum to "Hodgkin Lymphoma Cell Lines Are Characterized by a Specific miRNA Expression Profile." <i>Neoplasia</i> 2009, Feb;11(2):167-176.

Neoplasia (New York, N.Y.)·2019
Same author

HLA-G protein expression as a potential immune escape mechanism in classical Hodgkin's lymphoma.

Tissue antigens·2008
Same author

Anti-CD45RB monoclonal antibody prolongs renal allograft survival in cynomolgus monkeys.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons·2007
Same author

Regulation of pri-microRNA BIC transcription and processing in Burkitt lymphoma.

Oncogene·2006
Same author

The role of microRNAs in normal hematopoiesis and hematopoietic malignancies.

Leukemia·2006
Same author

Febuxostat for prevention of gout attacks.

Issues in emerging health technologies·2006

Direct brain involvement by chronic lymphocytic leukemia (CLL) is exceptionally rare, with only two documented cases. This report details a patient with CLL presenting with motor deficits, confirmed via biopsy as direct brain infiltration, highlighting a rare complication of the disease.

Area of Science:

  • Neurology
  • Oncology
  • Hematology

Background:

  • Direct brain involvement by chronic lymphocytic leukemia (CLL) is an exceedingly rare clinical presentation.
  • This case represents the second documented instance of CLL directly infiltrating the central nervous system.

Observation:

  • A 63-year-old male patient with CLL presented with new-onset motor deficits.
  • Initial conventional imaging was unremarkable, but MRI revealed a cerebellar lesion.
  • Cerebellar biopsy confirmed perivascular infiltration by small B lymphocytes, indicative of CLL.

Findings:

  • The patient received radiotherapy for the brain lesion.
  • Post-treatment, the patient experienced partial symptom improvement.
  • The patient survived for three years with residual neurological deficits.

Related Experiment Videos

Implications:

  • This case underscores the possibility of direct central nervous system (CNS) involvement in chronic lymphocytic leukemia.
  • It highlights the importance of advanced imaging and biopsy for diagnosing rare neurological complications of CLL.
  • Further research may elucidate mechanisms and optimal management strategies for CNS involvement in CLL.