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Indomethacin and recurrent ileal perforations in a preterm infant
G P Giacoia1, K Azubuike, J R Taylor
1Department of Pediatrics, University of Oklahoma College of Medicine, Tulsa.
Abstract:
This article reports a case of a very low birth weight infant who was given intravenous indomethacin for a symptomatic patent ductus arteriosus and subsequently had two isolated ileal perforations several days apart. Spontaneous or indomethacin-related ileal perforation appears to constitute a separate clinical and pathologic entity, different from necrotizing enterocolitis, with a benign clinical picture and good prognosis when promptly recognized.