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Attention-deficit hyperactivity disorder and thyroid function

R E Weiss1, M A Stein, B Trommer

  • 1Department of Medicine, University of Chicago, Illinois 60637.

The Journal of Pediatrics
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

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Children with attention-deficit hyperactivity disorder (ADHD) show a higher prevalence of thyroid abnormalities compared to the general population. This study screened 277 children with ADHD, finding a 5.4% rate of thyroid issues.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Neurodevelopmental Disorders

Background:

  • Attention-deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder with an unknown precise cause.
  • Thyroid abnormalities, including generalized resistance to thyroid hormone (GRTH), are observed in some children with ADHD.
  • The relationship between thyroid function and ADHD requires further investigation.

Purpose of the Study:

  • To prospectively screen for thyroid abnormalities in a cohort of children diagnosed with ADHD.
  • To determine the prevalence of thyroid dysfunction in children with ADHD.
  • To investigate potential links between ADHD and thyroid hormone resistance.

Main Methods:

  • Prospective screening of 277 children with ADHD.
  • Measurement of serum total thyroxine, free thyroxine index, and thyrotropin levels.

Related Experiment Videos

  • Detailed thyroid function testing in a subset of children with suspected GRTH.

    • Main Results:

    • Fourteen children (5.4%) with ADHD exhibited thyroid function test abnormalities.
    • No cases of generalized resistance to thyroid hormone (GRTH) were confirmed in the studied ADHD cohort.
    • The prevalence of thyroid abnormalities in children with ADHD is significantly higher than in the general population.

    Conclusions:

    • Thyroid abnormalities are more prevalent in children with ADHD than in the general population.
    • While GRTH is associated with ADHD, this study did not detect it in the screened ADHD population.
    • Further research is warranted to elucidate the specific mechanisms linking thyroid function and ADHD.