Related Experiment Video
Updated: Aug 13, 2026

Characteristics of Precipitation-formed Polyethylene Glycol Microgels Are Controlled by Molecular Weight of Reactants
Published on: December 23, 2013
Accumulation model for solutes leaching from polymeric containers
D R Jenke1, A V Martinez, L A Cruz
1Baxter Healthcare Corporation, William B. Graham Science Center, Round Lake, IL.
Abstract:
An accumulation model for predicting the equilibrium solution concentration of leachables migrating from polymeric containers has been applied to the leaching of several solutes from a blend of a styrene-butadiene-styrene block co-polymer and polypropylene. The model considers three accumulation-limiting mechanisms: total available pool, solute solubility and solute partitioning. Equations relating a solute's solvent-water partition coefficients (Po/w and Ph/w) and its polymer partitioning properties have been developed. With these equations, one can predict leachable accumulation from the container weight, solution volume and the solute's partition coefficients. The maximal accumulation of the leachable in solution will be the lowest value predicted via the three accumulation-limiting mechanisms.
Related Concept Videos
Expressing Solution Concentration
Concentrations may be quantitatively assessed using a wide variety of measurement units, each convenient for particular applications. Molarity (M) is a useful concentration unit for many applications in chemistry.
Factors Affecting Solubility
Compartment Models: Single-Compartment Model
Theories of Dissolution: Diffusion Layer Model
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
Theories of Dissolution: The Danckwerts' Model and Interfacial Barrier Model
Drug Accumulation During Multiple Dosing: Repetitive IV Injections

