Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Accumulation model for solutes leaching from polymeric containers

D R Jenke1, A V Martinez, L A Cruz

  • 1Baxter Healthcare Corporation, William B. Graham Science Center, Round Lake, IL.

Journal of Parenteral Science and Technology : a Publication of the Parenteral Drug Association
|July 1, 1993
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sertraline associated with gold nanoparticles reduce cellular toxicity and induce sex-specific responses in behavior and neuroinflammation biomarkers in a mouse model of anxiety.

Pharmacology, biochemistry, and behavior·2023
Same author

Chemical changes in concentrated, acidic, metal-bearing wastewaters when treated with lime.

Environmental science & technology·2012
Same author

Evaluation of model solvent systems for assessing the accumulation of container extractables in drug formulations.

International journal of pharmaceutics·2001
Same author

A multimodal assessment of sensory thresholds in aging.

The journals of gerontology. Series B, Psychological sciences and social sciences·1998
Same author

Development and validation of an ion-exclusion chromatographic method for the quantitation of organic acids in complex pharmaceutical products.

Journal of chromatographic science·1998
Same author

Spatial acuity of touch: ubiquitous decline with aging revealed by repeated threshold testing.

Somatosensory & motor research·1996
Same journal

Particle contamination in a ternary nutritional admixture.

Journal of parenteral science and technology : a publication of the Parenteral Drug Association·1993
Same journal

Optimization of moist heat sterilization.

Journal of parenteral science and technology : a publication of the Parenteral Drug Association·1993
Same journal

Factors affecting recovery of Neosartorya fischeri ascospores after exposure to dry heat.

Journal of parenteral science and technology : a publication of the Parenteral Drug Association·1993
Same journal

Moisture measurement: a new method for monitoring freeze-drying cycles.

Journal of parenteral science and technology : a publication of the Parenteral Drug Association·1993
Same journal

USP perspectives on particle contamination of injectable products.

Journal of parenteral science and technology : a publication of the Parenteral Drug Association·1993
Same journal

Depyrogenation of pharmaceutical solutions using submicron and ultrafilters.

Journal of parenteral science and technology : a publication of the Parenteral Drug Association·1993
See all related articles

A new model predicts leachable concentrations in polymeric containers by considering solubility and partitioning. This helps determine the maximum accumulation of substances migrating from plastics into solutions.

Area of Science:

  • Polymer science
  • Analytical chemistry
  • Chemical engineering

Background:

  • Leachables from polymeric containers can impact product quality and safety.
  • Predicting leachable concentrations is crucial for risk assessment and regulatory compliance.
  • Existing models may not fully account for all accumulation-limiting factors.

Purpose of the Study:

  • To develop and apply an accumulation model for predicting equilibrium leachable concentrations from polymeric materials.
  • To identify and quantify the key mechanisms limiting leachable accumulation.
  • To provide a predictive tool for estimating leachable levels based on material properties and conditions.

Main Methods:

  • An accumulation model was developed incorporating three limiting mechanisms: total available pool, solute solubility, and solute partitioning.

Related Experiment Videos

  • The model was applied to the leaching of solutes from a blend of styrene-butadiene-styrene block co-polymer and polypropylene.
  • Equations were derived relating solute partition coefficients (solvent-water and polymer-water) to accumulation predictions.

    • Main Results:

    • The model successfully predicted equilibrium solution concentrations of leachables.
    • The three accumulation-limiting mechanisms were quantified and shown to influence the maximum leachable concentration.
    • The developed equations enable prediction of leachable accumulation using container weight, solution volume, and solute partition coefficients.

    Conclusions:

    • The developed accumulation model provides a robust method for predicting leachable concentrations in polymeric containers.
    • Understanding solute partitioning and solubility is critical for accurate leachable accumulation prediction.
    • This model can aid in material selection and risk assessment for products stored in polymeric packaging.