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Dapsone poisoning
A Sheela1, R T Thachil, C B Sridhar
1Department of Medicine, St John's Medical College Hospital, Bangalore, India.
The Journal of Tropical Medicine and Hygiene
|October 1, 1993
Summary
Dapsone overdose can cause severe cyanosis and methaemoglobinaemia. Intravenous methylene blue therapy effectively treated these patients, leading to full recovery without lasting effects.
Area of Science:
- Toxicology
- Pharmacology
- Emergency Medicine
Background:
- Dapsone is an antibiotic with potential toxic effects at high doses.
- Suicidal ingestion of dapsone can lead to life-threatening complications.
Observation:
- Two patients presented with severe cyanosis and significant methaemoglobinaemia after intentional dapsone ingestion.
- One patient also exhibited acute psychosis and haemolytic anaemia.
Findings:
- Intravenous methylene blue administration was the primary treatment for methaemoglobinaemia.
- Nasal oxygen inhalation supported respiratory function.
Implications:
- Prompt recognition and treatment of dapsone-induced methaemoglobinaemia are crucial.
- Methylene blue is an effective antidote for dapsone toxicity.
- Patients can achieve complete recovery with appropriate medical intervention.
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