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Dapsone poisoning

A Sheela1, R T Thachil, C B Sridhar

  • 1Department of Medicine, St John's Medical College Hospital, Bangalore, India.

The Journal of Tropical Medicine and Hygiene
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

Dapsone overdose can cause severe cyanosis and methaemoglobinaemia. Intravenous methylene blue therapy effectively treated these patients, leading to full recovery without lasting effects.

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Area of Science:

  • Toxicology
  • Pharmacology
  • Emergency Medicine

Background:

  • Dapsone is an antibiotic with potential toxic effects at high doses.
  • Suicidal ingestion of dapsone can lead to life-threatening complications.

Observation:

  • Two patients presented with severe cyanosis and significant methaemoglobinaemia after intentional dapsone ingestion.
  • One patient also exhibited acute psychosis and haemolytic anaemia.

Findings:

  • Intravenous methylene blue administration was the primary treatment for methaemoglobinaemia.
  • Nasal oxygen inhalation supported respiratory function.

Implications:

  • Prompt recognition and treatment of dapsone-induced methaemoglobinaemia are crucial.
  • Methylene blue is an effective antidote for dapsone toxicity.
  • Patients can achieve complete recovery with appropriate medical intervention.