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Infection by echoviruses 1 and 8 depends on the alpha 2 subunit of human VLA-2
J M Bergelson1, N St John, S Kawaguchi
1Laboratory of Infectious Disease, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115.
Journal of Virology
|November 1, 1993
Abstract:
Anti-VLA-2 antibodies protected HeLa cells from infection by echoviruses 1 and 8 but not from infection by other echovirus serotypes. Echoviruses 1 and 8 bound to and infected nonpermissive hamster cells transfected with the alpha 2 subunit of human VLA-2. These results indicate that the human alpha 2 subunit is critical for infection by echoviruses 1 and 8 but that other echovirus serotypes must bind receptors other than VLA-2.