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Does fish oil benefit stone formers?

P J Rothwell1, R Green, N J Blacklock

  • 1Department of Urology, University Hospital of South Manchester, United Kingdom.

The Journal of Urology
|November 1, 1993
PubMed
Summary

Fish oil supplementation may help reduce urinary calcium excretion in patients with hypercalciuric urolithiasis. However, it had a limited overall impact on risk factors for recurrent kidney stones.

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Area of Science:

  • Nephrology
  • Nutritional Science
  • Urology

Background:

  • Hypercalciuric urolithiasis is a condition characterized by high urinary calcium levels, increasing the risk of kidney stone formation.
  • Dietary interventions, such as fish oil supplementation, are explored for their potential to manage this condition.

Purpose of the Study:

  • To investigate the effects of fish oil on calcium excretion and other urinary parameters in a rat model and in human patients with hypercalciuric urolithiasis.

Main Methods:

  • Rats were supplemented with fish oil and subjected to induced nephrocalcinosis.
  • A clinical study involved 18 patients with hypercalciuric recurrent stone disease who received fish oil supplementation.

Main Results:

  • Fish oil inhibited experimental nephrocalcinosis in rats without significant changes in urinary biochemistry.
  • In humans, fish oil significantly decreased urinary calcium excretion, accompanied by reduced magnesium and citrate excretion.
  • Urinary oxalate and fibrinolytic activity remained unchanged.

Conclusions:

  • Fish oil supplementation demonstrates a potential to lower urinary calcium levels in hypercalciuric individuals.
  • The overall effect of fish oil on the risk profile for recurrent urolithiasis appears limited, despite reducing calcium excretion.

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