Related Experiment Videos
Deep venous insufficiency: the relationship between lysis and subsequent reflux
M H Meissner1, R A Manzo, R O Bergelin
1Department of Surgery, University of Washington School of Medicine, Seattle 98119.
Journal of Vascular Surgery
|October 1, 1993
Summary
Early recanalization aids venous valve competence after deep vein thrombosis, except in the posterior tibial vein. Other factors may influence valve function, especially in this specific vein segment.
Area of Science:
- Vascular Medicine
- Venous Thromboembolism Research
- Postthrombotic Syndrome Etiology
Background:
- Venous valvular insufficiency is a key factor in postthrombotic syndrome development.
- The specific mechanisms causing valve incompetence after deep venous thrombosis (DVT) are not fully understood.
Purpose of the Study:
- To investigate the relationship between venous recanalization and valve competence following acute deep venous thrombosis.
- To identify factors influencing the development of valvular incompetence post-DVT.
Main Methods:
- Serial duplex ultrasonography was employed to assess 113 patients with acute deep venous thrombosis.
- Recanalization and valve competence were monitored over time using ultrasound imaging.
Main Results:
- Recanalization was significantly longer in venous segments that developed reflux, except for the posterior tibial vein.
- The onset of reflux occurred earlier than or simultaneous with recanalization in most venous segments.
- In the posterior tibial vein, recanalization time showed little correlation with the development of reflux.
Conclusions:
- Early recanalization is crucial for preserving venous valve integrity in most affected segments.
- Additional factors beyond recanalization influence valvular incompetence, particularly in the posterior tibial vein.
- Further research is needed to elucidate these additional factors contributing to post-DVT valvular dysfunction.