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Tissue oxygenation in hypovolemic shock

N A Pianim1, S Y Liu, S Dubecz

  • 1Department of Surgery, Harbor UCLA Medical Center, Torrance 90509.

The Journal of Surgical Research
|September 1, 1993
PubMed
Summary
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Hypovolemic shock rapidly decreases tissue oxygen tension (TPO2) in the bowel and skin. Subcutaneous TPO2 reflects bowel ischemia, offering insights beyond traditional oxygen delivery metrics.

Area of Science:

  • Physiology
  • Medical Research
  • Sepsis Pathophysiology

Background:

  • Bowel mucosal ischemia is linked to systemic sepsis development.
  • Traditional oxygen metabolism indices do not reflect tissue-specific oxygen concentration.

Purpose of the Study:

  • To examine the relationship between systemic oxygen delivery (DO2) and tissue oxygen tension (TPO2) in hypovolemic shock.

Main Methods:

  • A modified Wiggers model induced hypotension in swine.
  • Tissue oxygen tension (TPO2) was measured in bowel submucosa and subcutaneous tissue using fluorescence-quenching probes.
  • Systemic oxygen delivery (DO2) and hemodynamic parameters were monitored during shock and resuscitation.

Main Results:

Related Experiment Videos

  • Hypovolemic shock significantly decreased DO2, skin TPO2, and bowel TPO2.
  • Skin and bowel TPO2 levels correlated with DO2 and each other.
  • TPO2 returned to baseline levels upon resuscitation.

    • Conclusions:

    • Hypovolemic shock causes rapid decreases in bowel and subcutaneous TPO2, mirroring changes in DO2.
    • Subcutaneous TPO2 serves as a clinical indicator for the degree of bowel ischemia.
    • TPO2 offers valuable information on oxygen availability during shock and resuscitation, surpassing traditional parameters.