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Lymphoid Cells and Tissues

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Intravitreal large-cell lymphoma

H Buettner¹, J P Bolling

¹Department of Ophthalmology, Mayo Clinic Rochester, MN 55905.

Mayo Clinic Proceedings

|October 1, 1993

Summary

Ocular large-cell lymphoma, a type of non-Hodgkin's lymphoma, can affect the eye and mimic inflammatory conditions. Early diagnosis via vitreous biopsy and combined treatments have improved patient prognosis.

Area of Science:

Ophthalmology
Hematology
Oncology

Background:

Large-cell lymphoma can infiltrate ocular tissues, including the vitreous, uveal tract, retina, and optic nerve.
Ocular lymphoma often presents bilaterally (80% of cases) and may precede central nervous system involvement.
This condition typically affects individuals around 60 years old, with a higher prevalence in women.

Purpose of the Study:

To describe the clinical presentation, diagnosis, and management of ocular large-cell lymphoma.
To highlight the potential for ocular lymphoma to mimic other eye conditions.
To discuss recent advances in treatment and their impact on prognosis.

Main Methods:

Cytologic and immunocytochemical analysis of vitreous biopsy specimens obtained via aspiration or pars plana vitrectomy.

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Review of clinical data including patient demographics, ocular and systemic involvement, and treatment outcomes.

Main Results:

Ocular large-cell lymphoma can present as vitreous cellular infiltrates, mimicking uveitis or infectious diseases.
Diagnosis relies on specialized examination of vitreous samples.
Combined therapy involving irradiation, corticosteroids, and chemotherapy has led to improved outcomes.

Conclusions:

Ocular large-cell lymphoma requires a high index of suspicion due to its potential to mimic other ocular conditions.
Prompt diagnosis through vitreous biopsy is crucial for effective management.
Multimodal treatment strategies have significantly improved the prognosis for patients with ocular large-cell lymphoma.