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Pancreatic polypeptide stimulates corticosterone secretion by isolated rat adrenocortical cells
P G Andreis1, C Tortorella, G G Nussdorfer
1Department of Anatomy, University of Padua, Italy.
Life Sciences
|January 1, 1993
Abstract:
Pancreatic polypeptide (PP) dose-dependently enhanced both basal and submaximally ACTH-stimulated corticosterone production by dispersed zona fasciculata/reticularis cells of the rat adrenal gland. Conversely PP did not affect either basal or ACTH- and angiotensin-II-stimulated aldosterone and corticosterone secretion of zona glomerulosa cells. These findings could throw light on the physiological significance of the marked increase in the pancreatic release of PP during stresses.