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Peripheral neuromuscular manifestations in systemic sclerosis (scleroderma)

A Hietaharju1, S Jääskeläinen, H Kalimo

  • 1Department of Clinical Sciences, University of Tampere, Finland.

Muscle & Nerve
|November 1, 1993
PubMed
Summary

Peripheral neuropathy is more common in systemic sclerosis (scleroderma) than previously believed. This study found clinical or subclinical peripheral nervous system (PNS) involvement in over 30% of patients evaluated.

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Area of Science:

  • Neurology
  • Rheumatology
  • Immunology

Background:

  • Systemic sclerosis (scleroderma) is a collagen vascular disorder.
  • Nervous system damage is considered uncommon in systemic sclerosis.
  • Peripheral neuromuscular manifestations require further investigation.

Purpose of the Study:

  • To evaluate the prevalence of peripheral neuromuscular manifestations in patients with systemic sclerosis.
  • To determine if peripheral nervous system (PNS) involvement is underestimated in scleroderma.

Main Methods:

  • Clinical evaluation of 32 patients with scleroderma.
  • Neurophysiological studies to detect subclinical PNS involvement.
  • Assessment of peripheral nervous system (PNS) lesions and muscular disease.

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Main Results:

  • Peripheral nervous system (PNS) lesions were clinically identified in 16% of patients.
  • Subclinical PNS involvement was suggested by neurophysiological studies in an additional 19% of patients.
  • Defined primary muscular disease was found in only 16% of patients despite frequent subjective complaints.

Conclusions:

  • Peripheral neuropathy in systemic sclerosis (scleroderma) is more frequent than previously estimated.
  • Systemic sclerosis can manifest with various peripheral nervous system (PNS) involvements, including neuropathy.
  • Further research is warranted to understand the full spectrum of neurological complications in scleroderma.