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MRI hippocampal volumes and memory function before and after temporal lobectomy

M R Trenerry1, C R Jack, R J Ivnik

  • 1Department of Psychiatry and Psychology, Mayo Clinic and Mayo Foundation, Rochester, MN.

Neurology
|September 1, 1993
PubMed
Summary

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Preoperative MRI hippocampal volumes predict memory outcomes after temporal lobectomy for epilepsy. Larger left hippocampal volume before surgery correlates with poorer verbal and visual memory post-operation.

Area of Science:

  • Neurosurgery
  • Neurology
  • Neuroradiology

Background:

  • Intractable epilepsy often necessitates temporal lobectomy.
  • Assessing preoperative factors predicting postoperative memory function is crucial.

Purpose of the Study:

  • To investigate the relationship between preoperative MRI hippocampal volumes and memory test performance before and after temporal lobectomy.
  • To evaluate the predictive value of hippocampal volume on memory outcomes.

Main Methods:

  • Retrospective analysis of 44 left (LTL) and 36 right (RTL) temporal lobectomy patients.
  • Preoperative MRI for hippocampal volume measurement.
  • Neuropsychological memory testing before and after surgery (Wechsler Memory Scale-Revised).

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Main Results:

  • In LTL patients, the difference in hippocampal volumes (right minus left) significantly correlated with postoperative verbal memory change (r = 0.61, p < 0.001) and visual memory (r = 0.49, p < 0.005).
  • Resection of a larger left hippocampus in LTL patients was linked to poorer memory outcomes.
  • In RTL patients, larger right hippocampal volume correlated with visual-spatial learning decline, but not memory decline.

Conclusions:

  • Preoperative MRI hippocampal volume is a meaningful predictor of memory impairment risk following temporal lobectomy.
  • Understanding hippocampal volume can aid in surgical planning and patient counseling regarding memory function.