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Lipofuscin, the age pigment

G Wolf1

  • 1Department of Nutritional Sciences, University of California, Berkeley 94720.

Nutrition Reviews
|July 1, 1993
PubMed
Summary

Lipofuscin, a fluorescent compound mixture, accumulates with age in human tissues like the retina. A key component identified is N-retinylidene-N-retinylethanolamine, formed from retinaldehyde and phosphatidylethanolamine.

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Area of Science:

  • Ophthalmology
  • Biochemistry
  • Cell Biology

Background:

  • Lipofuscin is a fluorescent aggregate that accumulates in aging tissues.
  • The retinal pigment epithelium is a site of significant lipofuscin accumulation.
  • Understanding lipofuscin composition is crucial for aging research.

Purpose of the Study:

  • To identify major components of retinal lipofuscin.
  • To elucidate the origin of identified lipofuscin compounds.

Main Methods:

  • Spectroscopic analysis of retinal lipofuscin.
  • Chemical characterization of isolated lipofuscin components.

Main Results:

  • N-retinylidene-N-retinylethanolamine was identified as a substantial component of retinal lipofuscin.
  • This compound is likely formed from the reaction between retinaldehyde and phosphatidylethanolamine.

Conclusions:

  • N-retinylidene-N-retinylethanolamine is a key age-related component in retinal lipofuscin.
  • The formation pathway involves visual cycle intermediates and membrane lipids.

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