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Malignant acanthosis nigricans. A case report

C C Wedge1, D S Rootman, W Hunter

  • 1Department of Ophthalmology, University of Toronto, Ontario.

Ophthalmology
|October 1, 1993
PubMed
Summary
This summary is machine-generated.

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Malignant acanthosis nigricans, a skin condition, can be linked to lung cancer. This case highlights unusual eyelid involvement causing vision loss, emphasizing the importance of thorough investigation.

Area of Science:

  • Dermatology
  • Oncology
  • Ophthalmology

Background:

  • Malignant acanthosis nigricans (MAN) is a rare dermatological condition often associated with internal malignancies.
  • While typically linked to intra-abdominal cancers, its association with lung neoplasms is infrequent.

Observation:

  • A 65-year-old male presented with decreased vision, pruritus, and skin thickening, alongside distinctive papillomatous lesions on the eyelid margins.
  • Skin biopsy confirmed acanthosis nigricans, and further investigations revealed a suprahilar mass consistent with squamous cell carcinoma of the lung.

Findings:

  • The patient underwent surgical excision of the eyelid papillomata, with recurrence necessitating repeat surgery a year later.
  • Palliative radiotherapy was administered for the lung malignancy.

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Implications:

  • This case underscores the rare but significant association between malignant acanthosis nigricans and lung cancer.
  • The extensive ocular involvement and resulting visual impairment in this patient highlight the need for comprehensive ophthalmological evaluation in cases of MAN.