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Summary
Zinc, present in all insulin preparations, was identified as the cause of allergic reactions in two patients. This previously unrecognized allergy can be diagnosed with skin tests and considered in difficult insulin allergy cases.
Area of Science:
- Immunology
- Dermatology
- Endocrinology
Background:
- Local cutaneous hypersensitivity reactions can occur after insulin injections.
- The specific allergen responsible for these reactions is often unclear.