Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Growth-stimulating factor in regenerating canine liver

T E Starzl, A F Jones, J Terblanche

Lancet (London, England)

|January 20, 1979

Summary

Liver extracts from regenerating dog livers stimulate liver cell proliferation and counteract atrophy. This suggests a novel growth-control factor distinct from insulin or glucagon is present.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Adherence to a guided walking program with amelioration of cognitive functions in subjects with schizophrenia even during COVID-19 pandemic.

BMC sports science, medicine & rehabilitation·2022

Same author

Robotic transabdominal retromuscular rectus diastasis (r-TARRD) repair: a new approach.

Hernia : the journal of hernias and abdominal wall surgery·2022

Same author

Robotic-assisted single site (RASS) TAPP: an advantageous choice? : Outcomes of single site robotic groin hernia repair.

Hernia : the journal of hernias and abdominal wall surgery·2020

Same author

Genome-wide association studies for iris pigmentation and heterochromia patterns in Large White pigs.

Animal genetics·2020

Same author

Transcriptomics-genomics data integration and expression quantitative trait loci analyses in oocyte donors and embryo recipients for improving invitro production of dairy cattle embryos.

Reproduction, fertility, and development·2020

Same author

Improved percent-predicted peak VO<sub>2</sub> is associated with lower risk of hospitalization in patients with coronary heart disease. Analysis from the FRIEND registry.

International journal of cardiology·2020

Area of Science:

Hepatology
Regenerative Medicine
Molecular Biology

Background:

Portacaval shunts (Eck fistula) induce liver atrophy and hepatocyte damage.
The liver possesses a remarkable capacity for regeneration after injury.
Factors regulating liver growth and regeneration are not fully understood.

Purpose of the Study:

To investigate the effect of regenerating liver extracts on liver regeneration and atrophy.
To identify potential growth-control factors in regenerating liver tissue.
To determine if these factors can counteract the effects of Eck fistula.

Main Methods:

Hepatectomy was performed on dogs, followed by regeneration periods of 24, 48, and 72 hours.
Extracts from regenerating livers were infused into the portal vein of dogs with Eck fistula.

Related Experiment Videos

Liver lobes were analyzed for proliferative response, atrophy, and ultrastructural changes 2 and 3 days post-infusion.

Main Results:

Infusion of 48-h and 72-h regenerating liver extracts induced a delayed proliferative response, primarily in the left liver lobes.
These extracts reversed atrophy and prevented hepatocyte deterioration caused by Eck fistula.
The peak response occurred 3 days after extract infusion.

Conclusions:

Regenerating liver extracts contain factors that promote liver proliferation and protect against atrophy.
These factors are distinct from insulin and glucagon.
This finding opens avenues for therapeutic strategies targeting liver regeneration.