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Treatment of acute mania
1Department of Psychiatry, University of California at Los Angeles.
The Psychiatric Clinics of North America
|September 1, 1993
Summary
Effective acute mania treatment involves specific drugs like lithium, carbamazepine, and valproate, alongside nonspecific agents. For treatment-resistant cases, sequential strategies, including polypharmacy and electroconvulsive therapy, are recommended.
Area of Science:
- Pharmacology
- Neuroscience
- Psychiatry
Background:
- Acute mania management necessitates a dual approach, considering both specific and nonspecific pharmacological interventions.
- Current treatment paradigms for acute mania involve a range of established and emerging therapeutic options.
Purpose of the Study:
- To outline the pharmacological strategies for treating acute manic episodes.
- To discuss the management of treatment-resistant manic states.
Main Methods:
- Review of current pharmacological agents for acute mania.
- Discussion of treatment algorithms for resistant cases.
Main Results:
- Specific antimanic medications include lithium, carbamazepine, and valproate.
- Nonspecific agents encompass benzodiazepines, calcium channel blockers, alpha-adrenergic agonists, and neuroleptic drugs.
- Sequential strategies, potentially involving polypharmacy and electroconvulsive therapy, are indicated for treatment-resistant mania.
Conclusions:
- A comprehensive approach integrating specific and nonspecific medications is crucial for acute mania.
- Advanced interventions are available for managing refractory manic episodes, offering hope for improved patient outcomes.