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Infantile generalized pustular psoriasis associated with lytic lesions of the bone
R A Ivker1, C M Grin-Jorgensen, V K Vega
1Department of Medicine, University of Connecticut School of Medicine, Farmington 06030.
Insights
Generalized pustular psoriasis is rare in infants. This case study details an infant with early-onset generalized pustular psoriasis and sterile lytic bone lesions, highlighting treatment resistance.
Area of Science:
- Pediatric Dermatology
- Pediatric Rheumatology
- Clinical Case Study
Background:
- Generalized pustular psoriasis (GPP) is a rare, severe form of psoriasis.
- GPP is exceptionally uncommon in infants, particularly those under one year of age.
- Lytic bone lesions associated with psoriasis are infrequently reported in pediatric populations.
Abstract:
Generalized pustular psoriasis is rare in children, especially in those less than 1 year of age. Lytic lesions of the bone have been reported in children with psoriasis, but are rare. We describe an infant with the clinical and histopathologic features of generalized pustular psoriasis that began in the first few weeks of life. In addition, this patient had sterile lytic lesions of the bone. Despite significant improvement in the bone lesions, his skin condition was resistant to therapy.