Severe metabolic acidosis complicating massive ibuprofen overdose

Area of Science:

• Toxicology
• Emergency Medicine
• Critical Care

Background:

• Ibuprofen is a common nonsteroidal anti-inflammatory drug (NSAID) used for pain and inflammation.
• Overdose can lead to significant toxicity, including gastrointestinal, renal, and central nervous system effects.
• Severe metabolic acidosis is a rare but life-threatening complication of ibuprofen overdose.

Observation:

• A patient presented after ingesting a large quantity of ibuprofen.
• The patient developed profound metabolic acidosis, indicating severe systemic toxicity.
• Despite the critical condition, the patient received intensive medical care.

Findings:

• The patient survived the ibuprofen overdose and subsequent severe metabolic acidosis.
• This case demonstrates a positive outcome in a patient with extreme acid-base disturbance due to NSAID toxicity.
• Prompt and aggressive supportive care was crucial for recovery.

Implications:

• This case emphasizes the potential for severe acidosis in ibuprofen overdose and the need for vigilant monitoring.
• It highlights the efficacy of intensive care management in reversing life-threatening complications of drug overdose.
• Clinicians should consider aggressive treatment strategies for patients with severe metabolic acidosis following NSAID overdose.