Toxic effects of Iomex on rat after repeated oral administration

Administration of Iomex, petroleum fraction, at a dose level of 1 ml/kg for a period of 4 weeks did not produce any toxic symptoms in albino rats. At higher doses, however, the animals showed high incidence of mortality, reduction in food and water intake and loss in body weight. At necropsy, lungs were found to be congested and intestines hyperaemic. Histopathological examination revealed slight abnormalities in lungs, liver and kidney. The absolute organ weights decreased (liver, kidney, heart, spleen, lung, gonad, brain and adrenal), whereas relative weights increased. There was a significant fall in total erythrocyte (RBC) and total leucocyte (WBC) counts and haemoglobin content (Hb) was reduced. Increased lymphocytes with correspondingly decreased neutrophils were also observed. Serum and liver transaminases (GOT and GTP) showed enhanced activity.