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[Synthesis and anti-inflammatory activity of some indazole derivatives. 36. Azoles]
U Wrzeciono1, E Linkowska, K Majewska
1Lehrstuhl für Organische Chemie, Medizinischen Akademie, Poznań.
Die Pharmazie
|August 1, 1993
Abstract:
The synthesis of water soluble hydrochlorides of indazole derivatives 1b, 8 and 9 is described. By treating of 2,5-dinitroindazole with thiomorpholine 3-thiomorpholino-5-nitroindazole (10) and 3,5-dinitroindazole (11) in the form of the molecular compound 11a are obtained. The known indazole derivatives 1 and 7 as well as the newly synthesized hydrochlorides of 1b, 8 and 9 are, except of 8.HCl, less toxic than benzydamine hydrochloric (BZD). The same compounds show with some excepts a comparable or greater antiinflammatory effect than BZD in the carrageenin induced oedema test.