Nimodipine's functional benefits depend on lesion completeness in medial septal area

The effects of a 4-day nimodipine treatment (70 micrograms/kg IP beginning on the day of surgery) given to rats with lesions directed at the medial septal area were monitored for 120 days. Body weight, water intake, open-field activity, rearing, hole-poking, and repetitive motor acts were periodically measured through 120 postsurgical days. Although no differences were found in water intake between any of the groups, the body weights of rats with any medial septal damage, whether treated with nimodipine or not, were lower than rats with control operations by postsurgery day 120. Rats with any medial septal damage, whether treated with nimodipine or not, had lower rearing frequencies, rearing durations, and hole-poking frequencies than controls on all test days. However, rats with complete medial septal lesions treated with nimodipine exhibited movement in the open field and frequencies of stereotyped, species-typical acts similar to those of control rats by postsurgery day 60. This nimodipine effect was not observed in rats with partial lesions of the medial septal region. This study emphasizes that a brief administration of nimodipine shortly after brain damage can influence behavioral changes 40-60 days after surgery, but that this effect was not apparent in rats with only partial medial lesions.