Factors affecting the efficiency of filtration leukapheresis

Continuous flow filtration leukopheresis was performed on normal volunteer donors with and without intravenous administration of dexamethasone. Although granulocyte counts were increased in steroid treated donors and almost 20% more cells were presented to the filters, the final yield of granulocytes was slightly decreased and the efficiency of collection during a two- to three-hour leukapheresis was statistically significantly decreased.