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Neutropenic enterocolitis in patients without leukemia

O Abbasoglu1, M Cakmakçi

  • 1Department of General Surgery, Hacettepe University Medical School, Ankara, Turkey.

Surgery
|January 1, 1993
PubMed
Summary

Neutropenic enterocolitis can occur in nonleukemic patients due to various causes. While some cases are fatal, prompt medical or surgical intervention can lead to survival.

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Area of Science:

  • Gastroenterology
  • Oncology
  • Hematology

Background:

  • Neutropenic enterocolitis (NE) is a severe intestinal complication in patients with neutropenia, often associated with acute leukemia chemotherapy.
  • This study focuses on nonleukemic patients experiencing NE, highlighting diverse causes of neutropenia.

Observation:

  • Three cases of nonleukemic NE are presented, with neutropenia induced by dipyrone, multiple myeloma chemotherapy, and lung carcinoma chemotherapy.
  • Treatment approaches varied, including surgery for two patients and medical management for one.

Findings:

  • One patient with multiple myeloma undergoing surgical treatment for NE died due to sepsis and multiple organ failure.
  • The other two patients with nonleukemic NE survived their respective treatments.

Implications:

  • The findings underscore that neutropenic enterocolitis is not exclusive to leukemia patients.
  • Early diagnosis and appropriate management, whether medical or surgical, are crucial for improving outcomes in nonleukemic NE.
  • Further research into the causes, diagnosis, and optimal treatment strategies for nonleukemic NE is warranted.

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