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Related Experiment Videos

The A/J mouse lung as a model for developing new chemointervention strategies

S A Belinsky1, S A Stefanski, M W Anderson

  • 1Laboratory of Molecular Toxicology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709.

Cancer Research
|January 15, 1993
PubMed
Summary

This study shows the A/J mouse lung is a viable model for testing lung cancer chemo-intervention strategies. Combining cis-platinum with indomethacin or metoclopramide effectively reduced tumor growth.

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Area of Science:

  • Oncology
  • Pharmacology
  • Preclinical Research

Background:

  • The A/J mouse lung is a model for studying lung cancer.
  • Lung tumors were induced using 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.
  • Tumor development was staged 42 weeks post-carcinogen treatment.

Purpose of the Study:

  • To investigate the A/J mouse lung as a model for chemo-intervention strategies.
  • To evaluate the efficacy of cis-platinum alone and in combination with other agents.
  • To assess the impact of indomethacin, metoclopramide, and nifedipine on tumor growth.

Main Methods:

  • Induction of lung tumors in A/J mice.
  • Treatment with cis-platinum, indomethacin, metoclopramide, or nifedipine for 4 or 8 weeks.

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  • Histological analysis of pulmonary lesions and tumor growth.

    • Main Results:

    • Eight weeks of cis-platinum treatment reduced carcinoma size by 37%.
    • Combinations of cis-platinum with metoclopramide and/or indomethacin reduced tumor mass by 50-60%.
    • Indomethacin significantly enhanced cis-platinum's efficacy against adenocarcinomas; nifedipine diminished these effects.

    Conclusions:

    • The A/J mouse lung model is effective for evaluating lung cancer intervention therapies.
    • Combination therapies, particularly with indomethacin, show promise for controlling malignant lung tumor growth.
    • This model can also assess cancer prevention therapies for pulmonary hyperplasia.