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Related Experiment Videos

Theophylline effect on sleep in normal subjects

J Kaplan1, P A Fredrickson, S A Renaux

  • 1Sleep Disorders Center, Mayo Clinic Jacksonville, Fla 32224.

Chest
|January 1, 1993
PubMed
Summary

Oral theophylline significantly disrupts sleep quality in healthy adults. This medication increases arousals per sleep hour and reduces total sleep time, even at low doses.

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Area of Science:

  • Pharmacology
  • Sleep Medicine
  • Clinical Research

Background:

  • Theophylline is a medication commonly used for asthma.
  • Its effects on sleep in non-asthmatic individuals are not well understood.
  • Isolating theophylline's sleep effects from asthma symptoms is crucial.

Purpose of the Study:

  • To investigate the impact of oral theophylline on sleep quality in healthy, non-asthmatic subjects.
  • To determine if theophylline causes adverse effects on sleep parameters.

Main Methods:

  • A double-blinded, crossover study involving 10 healthy male subjects.
  • Subjects received either sustained-release theophylline (300 mg doses) or a placebo.
  • Sleep quality was assessed over two consecutive nights in a sleep laboratory.

Main Results:

  • Theophylline administration significantly increased arousals per sleep hour (19.3 vs. 15.9, p = .006).
  • Total sleep time was significantly reduced with theophylline (370.9 min vs. 399.45 min, p = .015).
  • Theophylline showed a significant adverse effect on overall sleep quality (p = .036).

Conclusions:

  • Low doses of oral theophylline significantly disturb sleep quality in normal, non-asthmatic individuals.
  • Theophylline has a negative impact on sleep continuity and duration.
  • Further research may be needed to understand the clinical implications of these findings.

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