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Related Experiment Videos

Enteric protein loss during shigellosis

M L Bennish1, M A Salam, M A Wahed

  • 1International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka.

The American Journal of Gastroenterology
|January 1, 1993
PubMed
Summary

Shigella infection causes protein-losing enteropathy, a condition where the intestines lose protein. This condition is more severe with Shigella dysenteriae type 1 and improves with effective antimicrobial therapy.

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Area of Science:

  • Gastroenterology
  • Infectious Diseases
  • Clinical Medicine

Background:

  • Shigellosis, a bacterial infection, can lead to severe dysentery.
  • Protein-losing enteropathy (PLE) is characterized by excessive protein loss through the gastrointestinal tract.

Purpose of the Study:

  • To investigate the occurrence and severity of protein-losing enteropathy during Shigella infections.
  • To assess the impact of Shigella species and antimicrobial treatment on PLE.

Main Methods:

  • Measured alpha 1-antitrypsin concentrations in stool samples from 110 adults with acute Shigella dysentery.
  • Analyzed correlations between alpha 1-antitrypsin levels, Shigella species, erythrocytes, serum protein, and treatment outcomes.

Main Results:

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  • Shigella infection was associated with elevated stool alpha 1-antitrypsin, indicating protein-losing enteropathy.
  • Protein-losing enteropathy was more severe in patients infected with Shigella dysenteriae type 1.
  • Higher alpha 1-antitrypsin levels were observed in patients with treatment failure, often due to resistant strains.

Conclusions:

  • Shigella infection induces a significant protein-losing enteropathy.
  • The severity of enteropathy correlates with the specific Shigella species and treatment efficacy.
  • Appropriate antimicrobial therapy can improve protein-losing enteropathy in shigellosis patients.