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Corneal endothelial cell counts after Molteno implantation
M L McDermott1, R P Swendris, D H Shin
1Kresge Eye Institute, Wayne State University School of Medicine, Detroit, Michigan 48201.
American Journal of Ophthalmology
|January 1, 1993
Summary
Molteno drainage shunts are effective for advanced glaucoma. Uncomplicated procedures showed minimal endothelial cell loss, suggesting safety for the cornea's health.
Area of Science:
- Ophthalmology
- Glaucoma Surgery
- Corneal Health
Background:
- Molteno drainage shunts are utilized for advanced glaucoma treatment.
- Intraocular foreign materials can potentially lead to corneal endothelial cell loss.
Purpose of the Study:
- To assess the impact of indwelling Molteno drainage shunts on corneal endothelial cells.
- To determine if Molteno shunt implantation causes significant endothelial cell loss in glaucoma patients.
Main Methods:
- A cohort of 19 patients with advanced aphakic or pseudophakic glaucoma underwent Molteno shunt implantation.
- Serial, masked endothelial cell counts were performed postoperatively.
- Follow-up duration ranged from 5.4 to 25.7 months.
Main Results:
- Average endothelial cell loss was 2 cells/mm²/month.
- The 95% confidence interval for cell loss was -10 to +7 cells/mm²/month.
- No clinically significant progressive endothelial cell loss was observed in uncomplicated cases.
Conclusions:
- Uncomplicated Molteno drainage shunt procedures did not demonstrate significant progressive endothelial cell loss.
- Further studies with larger patient cohorts and extended follow-up are needed to definitively assess long-term endothelial effects.