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Related Experiment Videos

Corticotropin releasing hormone-binding protein (CRH-BP): plasma levels decrease during the third trimester of normal

E A Linton1, A V Perkins, R J Woods

  • 1Department of Biochemistry and Physiology, University of Reading, Berks.

The Journal of Clinical Endocrinology and Metabolism
|January 1, 1993
PubMed
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Maternal plasma corticotropin-releasing hormone binding protein (CRH-BP) levels remain stable during early pregnancy but drop significantly in the third trimester. This decline in CRH-BP increases bioactive CRH availability near term.

Area of Science:

  • Endocrinology
  • Reproductive Biology
  • Maternal-Fetal Medicine

Background:

  • Maternal plasma corticotropin-releasing hormone (CRH) increases in late pregnancy, but adrenocorticotropic hormone (ACTH) levels remain normal.
  • A CRH-binding protein (CRH-BP) inactivates CRH, potentially explaining normal ACTH levels during gestation.

Purpose of the Study:

  • To measure CRH-BP levels in plasma during human pregnancy.
  • To investigate the changes in CRH-BP throughout gestation and postpartum.

Main Methods:

  • Radioimmunoassay was used to measure CRH-BP in plasma.
  • Samples were collected from non-pregnant individuals, pregnant women in the first/second trimesters, and sequentially in the third trimester.

Main Results:

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  • CRH-BP levels in non-pregnant individuals averaged 4.46 nmol/L.
  • CRH-BP levels were similar in the first and second trimesters (4.46 nmol/L) and showed no correlation with gestational age.
  • CRH-BP levels significantly decreased in the third trimester (4.56 nmol/L at 30-35 weeks to 1.84 nmol/L at 38-40 weeks, P < 0.001) and recovered postpartum within 48 hours.

Conclusions:

  • CRH-BP levels are stable until late pregnancy.
  • A significant drop in CRH-BP occurs at term, increasing free, bioactive CRH availability.
  • This increase in bioactive CRH may stimulate maternal ACTH release or act on peripheral receptors near delivery.