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Related Experiment Videos

Correlation between antisaccade and Wisconsin Card Sorting Test performance in schizophrenia

R B Rosse1, B L Schwartz, S Y Kim

  • 1Department of Veterans Affairs Medical Center, Georgetown University School of Medicine, Washington, D.C. 20422.

The American Journal of Psychiatry
|February 1, 1993
PubMed
Summary

Cognitive deficits in chronic schizophrenia patients were assessed using eye movement tasks. Impaired antisaccade performance correlated with executive function deficits, but not with general cognitive or negative symptom scores.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Cognitive Psychology

Background:

  • Schizophrenia is a complex mental disorder associated with significant cognitive impairments.
  • Executive function deficits are a core feature of schizophrenia, impacting daily functioning.
  • Eye movement abnormalities, particularly in antisaccade tasks, are frequently observed in schizophrenia.

Purpose of the Study:

  • To investigate the relationship between antisaccade eye movement task performance and specific cognitive domains in patients with chronic schizophrenia.
  • To determine if antisaccade task performance correlates with executive function, general cognitive status, or negative symptoms.

Main Methods:

  • A cohort of 27 patients diagnosed with chronic schizophrenia was assessed.
  • Participants completed an antisaccade eye movement task.

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  • Cognitive performance was evaluated using the Wisconsin Card Sorting Test, the modified Mini-Mental State examination, and the Schedule for the Assessment of Negative Symptoms in Schizophrenia.

    • Main Results:

    • A significant positive correlation was found between antisaccade task performance and performance on the Wisconsin Card Sorting Test, indicating a link with executive function.
    • No significant correlation was observed between antisaccade performance and scores on the modified Mini-Mental State examination or the Schedule for the Assessment of Negative Symptoms in Schizophrenia.
    • Antisaccade task performance in schizophrenia patients was significantly impaired compared to 12 healthy control subjects.

    Conclusions:

    • Antisaccade task performance is significantly associated with executive function deficits in chronic schizophrenia.
    • The findings suggest that antisaccade tasks may serve as a potential biomarker for executive dysfunction in schizophrenia.
    • Further research is warranted to explore the clinical utility of antisaccade tasks in schizophrenia assessment and treatment.