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Evolution of the ets gene family
V Laudet1, C Niel, M Duterque-Coquillaud
1CNRS UA 1160, Institut Pasteur, Lille, France.
Biochemical and Biophysical Research Communications
|January 15, 1993
Summary
The ets family of transcription factors, including c-ets-1, is ancient. Phylogenetic analysis reveals gene duplication predates the split between arthropods and vertebrates over 500 million years ago.
Area of Science:
- Evolutionary biology
- Molecular genetics
- Bioinformatics
Background:
- The ets gene family encodes transcription factors regulating diverse cellular processes.
- Numerous ets-related genes have been identified across various organisms.
- The evolutionary history and origin of the ets gene family remain largely unexplored.
Purpose of the Study:
- To investigate the evolutionary origins of the ets gene family.
- To determine the ancientness of ets-related protein duplications.
- To establish the phylogenetic relationships among ets family members.
Main Methods:
- Phylogenetic tree construction using multiple analytical methods.
- Comparative analysis of ets gene sequences from different organisms.
- Bioinformatic analysis of protein sequence similarities.
Main Results:
- The ets gene family is evolutionarily ancient.
- Gene duplication events within the ets family occurred before the divergence of arthropods and vertebrates.
- Phylogenetic analyses consistently support an ancient origin for the ets gene family.
Conclusions:
- The ets transcription factor family has a deep evolutionary root.
- The diversification of ets genes predates major animal phyla divergences.
- Understanding the ancient origins of ets genes provides insights into their conserved functions.