[Experience with the use of cyclophosphamide in multiple sclerosis]

The effect of cyclophosphamid on the development of disseminated sclerosis was studied in 85 patients. For this purpose the authors used a special scale for the assessment of neurological expressions of the disease and the remote results of treatment. The effectiveness depended mainly on the degree of severity. Satisfactory results directly following treatment were attained in patients with light and middle degrees of disseminated sclerosis. A significant regress of pathological signs on behalf of the motor (28%), sensory (37%) spheres and cranial innervation (38%) was marked. The remote results (after 6--12 months) point to the absence of development of the process. The use of cyclophosphamides was accompanied by a drop in the level of gamma-globulins in the blood serum of patients with disseminated sclerosis.