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[Experience with the use of cyclophosphamide in multiple sclerosis]
Zhurnal Nevropatologii I Psikhiatrii Imeni S.S. Korsakova (Moscow, Russia : 1952)
|January 1, 1977
Summary
Cyclophosphamide treatment showed effectiveness in mild to moderate disseminated sclerosis, halting disease progression and reducing neurological symptoms. Patients experienced significant improvements in motor, sensory, and cranial functions with sustained benefits.
Area of Science:
- Neurology
- Immunology
Context:
- Disseminated sclerosis (DS) is a chronic neurological disease.
- Assessing treatment efficacy requires standardized neurological assessments and long-term follow-up.
Purpose:
- To evaluate the therapeutic effect of cyclophosphamide on the development of disseminated sclerosis.
- To assess neurological manifestations and treatment outcomes in DS patients.
Summary:
- Cyclophosphamide treatment was administered to 85 patients with disseminated sclerosis.
- Effectiveness was correlated with disease severity, showing significant benefits in mild to moderate cases.
- Improvements were observed in motor (28%), sensory (37%), and cranial innervation (38%) functions.
- Long-term follow-up (6-12 months) indicated a cessation of disease progression.
- Cyclophosphamide use led to a reduction in serum gamma-globulin levels.
Impact:
- Cyclophosphamide demonstrates potential as a treatment for disseminated sclerosis, particularly in early stages.
- The study highlights the importance of disease severity in predicting treatment response.
- Findings suggest a modulatory effect of cyclophosphamide on the immune system in DS patients, indicated by decreased gamma-globulins.