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Successful treatment of severe refractory sulfonylurea-induced hypoglycemia with octreotide
A J Krentz1, P J Boyle, K M Justice
1Diabetic Clinic, General Hospital, Birmingham, United Kingdom.
Objective:
To test the clinical use of octreotide in the treatment of sulfonylurea-induced hypoglycemia.
Research Design And Methods:
A case is reported of sulfonylurea-induced hypoglycemic coma in a nondiabetic subject, which was complicated by relapse of hypoglycemia after resuscitation with intravenous dextrose. Subcutaneous octreotide, 50 micrograms 12 hourly, suppressed stimulated endogenous insulin secretion, thereby preventing a further recurrence of hypoglycemia.
Results:
No adverse effects of treatment were observed.
Conclusions:
These results suggest a significant role for octreotide as an adjunct to intravenous dextrose in the management of severe and refractory cases of sulfonylurea-induced hypoglycemia.