Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Polysialic acids: potential in drug delivery

G Gregoriadis1, B McCormack, Z Wang

  • 1Centre for Drug Delivery Research, School of Pharmacy, University of London, UK.

FEBS Letters
|January 11, 1993
PubMed
Summary

Bacterial polysialic acids can extend drug circulation time in mice. This research suggests polysialic acids can improve drug delivery systems, prolonging pharmacological action.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Harnessing the Collective Power of Gender Equity and Diversity in Nursing.

Journal of advanced nursing·2025
Same author

Workplace culture in psychiatric nursing described by nurses.

Scandinavian journal of caring sciences·2017
Same author

Improving skills and care standards in the support workforce for older people: a realist synthesis of workforce development interventions.

BMJ open·2016
Same author

Nurses' perceptions of workplace culture in primary health care in Finland.

International nursing review·2015
Same author

The National Single Assessment Tool (SAT) a pilot study in older persons care-survey results.

Irish medical journal·2013
Same author

Protein kinase A regulatory subunit isoforms regulate growth and differentiation in Mucor circinelloides: essential role of PKAR4.

Eukaryotic cell·2012

Area of Science:

  • Biochemistry
  • Pharmacology
  • Biomaterials

Background:

  • Polysialic acids are bacterial polysaccharides with potential biomedical applications.
  • Understanding their pharmacokinetic properties is crucial for drug development.

Purpose of the Study:

  • To investigate the in vivo pharmacokinetics of bacterial polysialic acids.
  • To evaluate their potential as drug carriers for extending drug half-life.

Main Methods:

  • Intravenous injection of various bacterial polysialic acids into mice.
  • Determination of blood circulation half-lives.
  • Coupling of a model drug (fluorescein) to polysialic acid to assess carrier effects.

Main Results:

  • Polysialic acid half-lives varied (up to 40 hours) and were influenced by structure and modifications.
  • Deacylation increased half-life; shorter chains decreased it.
  • Drug half-life matched that of the polysialic acid carrier.
  • Pharmacokinetics were dose-independent.

Conclusions:

  • Polysialic acids, in various forms, can significantly prolong the circulation time of drugs and biomolecules.
  • These findings support the use of polysialic acids in advanced drug delivery systems.
  • Polysialic acids offer a promising strategy for enhancing therapeutic efficacy through extended pharmacological action.

Related Experiment Videos