Related Experiment Videos
Forskolin stimulates porcine sperm capacitation by increasing calcium uptake
1Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Japan.
FEBS Letters
|February 1, 1993
Abstract:
Using the fluorescent calcium indicator fura-2, forskolin was found to dose-dependently cause an immediate increase in the concentration of intracellular free calcium of porcine cauda epididymal sperm. This stimulatory effect of forskolin is due to the enhancement of Ca2+ uptake by the verapamil-sensitive transporter on the sperm plasma membrane and results in the promotion of the sperm capacitation and subsequent acrosome reaction.