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A protein required for secretion of cholera toxin through the outer membrane of Vibrio cholerae
M Sandkvist1, V Morales, M Bagdasarian
1Department of Microbiology, Michigan State University, East Lansing 48824.
Gene
|January 15, 1993
Abstract:
A gene essential for the secretion of cholera toxin from the periplasm of Vibrio cholerae into the extracellular medium has been isolated and its nucleotide sequence determined. It encodes a cytoplasmic protein of 56 kDa that exhibits a high degree of similarity to gene products required for extracellular protein secretion in several other Gram- organisms. Sequence similarities in its potential ATP-binding site suggest that the protein may act as an energy provider or signal transducer in the process of extracellular secretion.