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Antiphospholipid syndrome

R A Asherson1, R Cervera

  • 1Division of Rheumatology and Connective Tissue Diseases, Roosevelt/St. Luke's Hospital Center, New York, New York 10019.

The Journal of Investigative Dermatology
|January 1, 1993
PubMed
Summary
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Antiphospholipid antibodies (aPL) are linked to thrombosis and fetal loss in antiphospholipid syndrome. This review highlights the various skin lesions associated with this autoimmune condition.

Area of Science:

  • Immunology
  • Rheumatology
  • Dermatology

Background:

  • Antiphospholipid antibodies (aPL), including lupus anticoagulant and anticardiolipin antibodies, target negatively charged phospholipids.
  • Patients with aPL are susceptible to thrombosis, fetal losses, and thrombocytopenia, defining antiphospholipid syndrome.
  • Various dermatologic manifestations are observed in antiphospholipid syndrome.

Purpose of the Study:

  • To review the immunologic and clinical features of antiphospholipid syndrome.
  • To emphasize the dermatologic manifestations associated with antiphospholipid syndrome.

Main Methods:

  • Literature review of studies on antiphospholipid antibodies and antiphospholipid syndrome.
  • Compilation and analysis of reported dermatologic findings in patients with antiphospholipid syndrome.

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Main Results:

  • Antiphospholipid syndrome is characterized by aPL, thrombosis, fetal losses, and thrombocytopenia.
  • Common skin lesions include livedo reticularis, livedoid vasculitis, cutaneous infarctions, and gangrene.
  • Less common skin findings include discoid lupus and Degos' disease.

Conclusions:

  • Antiphospholipid syndrome has significant clinical manifestations, particularly dermatologic ones.
  • Understanding these skin lesions is crucial for diagnosing and managing antiphospholipid syndrome.
  • Further research into the pathogenesis of aPL-associated skin conditions is warranted.