Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Phototesting in lupus erythematosus

P Kind1, P Lehmann, G Plewig

  • 1Department of Dermatology, Ludwig-Maximilians University Munich, F.R.G.

The Journal of Investigative Dermatology
|January 1, 1993
PubMed
Summary

Ultraviolet (UV) irradiation significantly impacts lupus erythematosus pathogenesis. Standardized phototesting aids in defining photosensitivity in subacute cutaneous lupus erythematosus (SCLE) and lupus erythematosus tumidus, improving diagnosis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Does SAPHO syndrome exist in dermatology?

Journal of the European Academy of Dermatology and Venereology : JEADV·2022
Same author

Pioneers in Dermatology and Venereology: an interview with Prof. Gerd Plewig.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Investigation of gamma secretase gene complex mutations in German population with Hidradenitis suppurativa designate a complex polygenic heritage.

Journal of the European Academy of Dermatology and Venereology : JEADV·2021
Same author

Lipschütz genital ulcer revisited: is juvenile gangrenous vasculitis of the scrotum the male counterpart?

Journal of the European Academy of Dermatology and Venereology : JEADV·2019
Same author

Isotretinoin's paradoxical effects in immortalized sebocytes.

The British journal of dermatology·2018
Same author

T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities.

The British journal of dermatology·2018

Area of Science:

  • Dermatology
  • Immunology
  • Photobiology

Background:

  • Ultraviolet (UV) irradiation is a key factor in the pathogenesis of specific cutaneous lupus erythematosus variants.
  • Photosensitivity is a diagnostic criterion for systemic lupus erythematosus, highlighting its clinical significance.
  • The exact mechanisms of UV-induced lupus erythematosus are not fully understood.

Purpose of the Study:

  • To review phototest procedures, results, and clinical correlations in different lupus erythematosus subgroups.
  • To discuss the role of standardized testing in defining photosensitivity in lupus erythematosus.
  • To explore photosensitivity in subacute cutaneous lupus erythematosus (SCLE) and lupus erythematosus tumidus.

Main Methods:

  • Review of phototest procedures and results.

Related Experiment Videos

  • Analysis of clinical data and correlations in lupus erythematosus subgroups.
  • Standardized UV-A and UV-B testing to reproduce cutaneous lesions.

    • Main Results:

    • Standardized phototesting provides a more precise definition of photosensitivity compared to clinical history alone.
    • Subacute cutaneous lupus erythematosus (SCLE) and lupus erythematosus tumidus exhibit pronounced photosensitivity.
    • Phototest results and clinical correlations were analyzed across different patient subgroups.

    Conclusions:

    • Standardized phototesting is crucial for characterizing photosensitivity in lupus erythematosus.
    • UV irradiation plays a significant role in the pathogenesis of SCLE and lupus erythematosus tumidus.
    • Further research into UV-induced lupus mechanisms is warranted.