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Minireview: Molecular genetics in affective illness

J Mendlewicz1, S Sevy, K Mendelbaum

  • 1Department of Psychiatry, Erasme University Hospital, Brussels, Belgium.

Life Sciences
|January 1, 1993
PubMed
Summary

Genetic studies suggest manic depressive illness (MDI) may be linked to a specific region on the X chromosome (Xq27-28). However, further research is needed due to limitations in current findings.

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Area of Science:

  • Genetics
  • Psychiatry
  • Molecular Biology

Background:

  • Manic depressive illness (MDI), also known as bipolar disorder, has a complex genetic transmission.
  • Previous research utilized twin, adoption, association, and linkage studies to explore MDI's genetic basis.

Purpose of the Study:

  • To review genetic studies investigating the transmission patterns of manic depressive illness.
  • To evaluate the evidence for X-linked and autosomal transmission hypotheses of MDI.

Main Methods:

  • Review of genetic studies including twin, adoption, association, and linkage analyses.
  • Examination of various genetic markers on the X chromosome (e.g., Xg blood group, G6PD, DNA probes) and autosomes (e.g., O blood group, HLA, dopamine receptor genes).

Main Results:

  • Linkage studies provide support for a major locus involved in MDI transmission located in the Xq27-28 region.
  • Evidence for autosomal transmission was explored through association and linkage studies on chromosomes 9, 6, and 11.

Conclusions:

  • The Xq27-28 region is a potential major locus for MDI transmission.
  • Several factors currently limit the definitive conclusions from genetic studies on MDI transmission.

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