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Related Experiment Videos

Ranitidine has no effect on postbreakfast ethanol absorption

A G Fraser1, M Hudson, A M Sawyerr

  • 1University Department of Medicine, Royal Free Hospital School of Medicine, London, England.

The American Journal of Gastroenterology
|February 1, 1993
PubMed
Summary

Ranitidine, an H2-receptor antagonist, did not significantly alter the systemic bioavailability of ethanol when taken after a meal. This study found no clinically significant interaction between ranitidine and low-dose oral ethanol.

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Area of Science:

  • Pharmacology
  • Gastroenterology

Background:

  • Ranitidine is an H2-receptor antagonist used to reduce stomach acid.
  • Ethanol (alcohol) absorption can be influenced by various factors, including food and medications.
  • Understanding drug-food-alcohol interactions is crucial for patient safety.

Purpose of the Study:

  • To investigate the effect of ranitidine on the systemic bioavailability of orally administered ethanol.
  • To determine if ranitidine clinically interacts with a low dose of ethanol consumed after a meal.

Main Methods:

  • A randomized, placebo-controlled, double-blind, cross-over study was conducted.
  • Twenty healthy male subjects received either 150 mg ranitidine or placebo twice daily for 8 days.
  • Plasma ethanol concentrations were measured for 240 minutes after oral ethanol ingestion (0.3 g/kg) taken 1 hour after breakfast.

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Main Results:

  • Ranitidine administration resulted in nonsignificant changes in mean integrated 4-h plasma ethanol concentration (27.8 vs. 32.4 mg.h/dl) compared to placebo.
  • Peak plasma ethanol concentration (18.0 vs. 21.1 mg/dl) and time to peak (43 vs. 40 min) were also not significantly affected by ranitidine.
  • No clinically significant interaction was observed between ranitidine and low-dose oral ethanol.

Conclusions:

  • Ranitidine does not significantly alter the systemic bioavailability of a low dose of ethanol when taken 1 hour after breakfast.
  • There is no clinically important interaction between ranitidine and ethanol in this specific consumption context.
  • These findings suggest that concurrent use of ranitidine and low-dose ethanol after meals is unlikely to cause significant pharmacokinetic interactions.