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Suppression of adjuvant-induced arthritis in DA rats by incomplete Freund's adjuvant
G W Cannon1, M M Griffiths, M L Woods
1Salt Lake City Veterans Affairs Medical Center, UT.
Objective:
To define the effects of incomplete Freund's adjuvant (ICFA) on subsequent arthritis induced by complete Freund's adjuvant (CFA) and type II collagen (CII) in DA and Lewis rats.
Methods:
ICFA was injected into DA and Lewis rats before CFA or CII injection.
Results:
DA rats previously injected with ICFA had significantly less severe arthritis induced by CFA compared with those not receiving ICFA pretreatment (P < 0.01). ICFA had no significant impact on CFA-induced arthritis in Lewis rats or on CII-induced arthritis in DA rats.
Conclusion:
The injection of ICFA alone specifically suppresses subsequent CFA-induced arthritis in DA rats, but not in Lewis rats.