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Cardiovascular abnormalities in the Beckwith-Wiedemann syndrome
American Journal of Diseases of Children (1960)
|March 1, 1977
Insights
Most patients with Beckwith-Wiedemann syndrome experience cardiovascular abnormalities, including congenital heart disease and cardiomegaly. These heart conditions are common in individuals diagnosed with this genetic overgrowth disorder.
Area of Science:
- Cardiology
- Genetics
- Pediatrics
Background:
- Beckwith-Wiedemann syndrome is a rare genetic overgrowth disorder.
- Cardiovascular complications are a known concern in Beckwith-Wiedemann syndrome.
Purpose of the Study:
- To investigate the prevalence and types of cardiovascular abnormalities in patients with Beckwith-Wiedemann syndrome.
Main Methods:
- Retrospective analysis of 13 patients diagnosed with Beckwith-Wiedemann syndrome.
- Clinical evaluation and echocardiographic assessment of cardiac function and structure.
Main Results:
- Twelve out of 13 patients (92%) exhibited cardiovascular abnormalities.
- Congenital heart disease was diagnosed in 7 patients, while 5 presented with isolated cardiomegaly.
- No single type of cardiac defect was predominant.
Conclusions:
- Cardiovascular abnormalities are highly prevalent in Beckwith-Wiedemann syndrome.
- Early cardiac screening is crucial for early detection and management of heart conditions in these patients.
Abstract:
Twelve of 13 patients with Beckwith-Wiedemann syndrome were found to have cardiovascular abnormalities: congenital heart disease in 7 of the 12 and isolated cardiomegaly in the others. No specific type of cardiac abnormality predominated.