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Reye syndrome without initial hepatic involvement

M M Applebaum, M M Thaler

American Journal of Diseases of Children (1960)

|March 1, 1977

Summary

This summary is machine-generated.

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Reye syndrome can present with neurological symptoms before liver involvement is detected. This case highlights that encephalopathy may precede liver disease in Reye syndrome, suggesting other factors in its development.

Area of Science:

Neurology
Pediatrics
Hepatology

Background:

Reye syndrome is a rare but serious condition affecting children and adolescents.
It is characterized by acute encephalopathy and fatty liver degeneration.

Observation:

An 11-year-old boy presented with seizures and coma, initially without signs of liver disease.
Elevated liver enzymes (serum glutamic oxaloacetic transaminase, lactate dehydrogenase) and prolonged prothrombin time appeared later.
Increased blood ammonia levels were noted on the fourth day of coma.

Findings:

The case confirmed Reye syndrome through liver biopsy and autopsy.
Encephalopathy preceded detectable hepatic involvement, challenging typical diagnostic timelines.
Biochemical markers of liver injury emerged after neurological symptoms.

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Implications:

This case suggests encephalopathy in Reye syndrome can occur independently of overt liver disease.
It indicates that non-hepatic factors may contribute to Reye syndrome pathogenesis.
Highlights the need to consider Reye syndrome even with atypical initial presentations.