Topical progesterone in treatment of vulvar dystrophy: preliminary report of five cases

Topical progesterone was used in five cases of chronic vulvar dystrophy which were confirmed by biopsy. Good results were obtained in three of the cases through the sole use of topical progesterone. In one case, topical testosterone was substituted for the progesterone, and it was not as effective. The concomitant use of estrogen vaginal cream was required in order to achieve maximum results in another case due to the presence of senile vaginitis. The apparent failure of the progesterone preparation to achieve satisfactory results in a diabetic patient could possibly be explained by the presence of neurodermatitis.