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Labial melanotic macule: a clinical, histopathologic, and ultrastructural study
K K Ho1, P Dervan, S O'Loughlin
1Regional Centre of Dermatology, Mater Misercordiae Hospital, Dublin, Ireland.
Journal of the American Academy of Dermatology
|January 1, 1993
Summary
Labial melanotic macules (LMM) are benign pigmentary anomalies that can mimic melanoma. Histological and immunohistochemical analysis confirms their distinct, non-cancerous nature.
Area of Science:
- Dermatology
- Pathology
- Oncology
Background:
- Labial melanotic macule (LMM) is a recently identified pigmentary anomaly.
- LMM can be mistaken for malignant melanoma, necessitating accurate diagnosis.
Purpose of the Study:
- To define the clinical, histological, and immunohistochemical characteristics of LMM.
- To differentiate LMM from potentially malignant pigmented lesions.
Main Methods:
- Clinical data from 36 LMMs in 29 patients were analyzed.
- Histopathological examination was performed on 21 lesions.
- Immunohistochemistry (HMB-45 antibody) and electron microscopy were utilized.
Main Results:
- Most patients were women with solitary lesions on the lower lip, with onset around age 30.
- Histology showed prominent basilar hyperpigmentation without atypia or nevoid formation.
- Immunohistochemistry revealed HMB-45 negative melanocytes, and electron microscopy showed abundant melanosomes.
Conclusions:
- Labial melanotic macule is a clinically and histologically distinct benign pigmentary anomaly.
- Findings support the benign nature of LMM, aiding in differential diagnosis.